Author(s): Anand S*, Ajantha , Shashirekha K S, Geetha Nayak S
Urinary tract infections in human beings are associated with high morbidity and long term complications. Lakshanas of Pittaja mutrakrichra and symptoms of urinary tract infections are analogues. In majority, causative organisms of urinary tract infections are gram-negative bacteria viz. Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis etc. Klebsiella pneumoniae is the foremost micro-organism causing nosocomial infections including Urinary tract infection. Krimighna action of Ayurveda drug has to be re-investigated in line with modern scientific parameters to generate evidence and thereby to facilitate administration in patient against specific causative bacteria as Upashaya. This is achieved through tools like culture and sensitivity in vitro. Guduchi (Tinospora cordifolia Miers.) isindicated in mutrakrichra and said to possess krimighna property. Present work is planned to envisage various attributes of the microorganism Klebsiella pneumoniae by culture and sensitivity with Guduchi in patients suffering from Pittaja Mutrakrichra with special reference to Urinary tract infection. Patients of Pittaja mutrakrichra were subjected for urine culture and those with positive results for Klebsiella pneumoniae were further used. Alcoholic extract of Guduchi was prepared by Soxhlet method. Further sensitivity test was performed by Agar well diffusion method and zone of inhibition was measured. Alcoholic extract of Guduchi has showed better antibacterial effect against Klebsiella pneumoniae. Alcoholic extract contains active phytochemical components and these components aid in antibacterial action against cell membrane of micro-organism.