Author(s): Shishir Mishra*, Jamuna Rani R., Kumaraswamy Dabburu
Diabetes & its secondary complication have taken a troll over the past three decades. The picture is bleaker considering the elderly population is on rise. Endocannabinoid system (ECS) plays crucial role in bridging gaps between oxidative stress, calcium signalling, appetite regulation & accelerated aging mechanism in diabetic person. Current antidiabetic therapies have failed to address many relevant aspect of diabetes. The meshwork of various mechanism ECS participate in, provides many opportunities for development of new drugs for management of disorder like diabetes, dyslipidaemias, obesity, cognitive decline due to diabetes & many more. Some these have already been studied extensively. Still many pathways remain less highlighted. Reason for cognitive decline in diabetes appears especially more to do with endocannabinoid system, due to its widespread effects on all changes occur in cognitive decline.