Author(s): Amudha S.*, Prabal Kumar Manna, Jeganathan N.S.
The objective of the study was to develop a novel Phytosome formulation of Syzygium cumini capsules by incorporation of phospholipids, for the improved permeability, solubility and better physical characteristics. The Syzygium cumini phytosome capsules were prepared by using Thin Film Hydration Technique method and were optimized. The formations of phytosomes were analyzed for microscopic view, SEM, TEM, measurement of particle size & zeta potential, drug entrapment efficiency, drug content, In vitro dissolution studies and also the release kinetics of Syzygium cumini phytosomes complex. The Syzygium cumini phytosome capsules prepared by using Thin Film Hydration Technique showed a good microscopic view and practical yield, the drug content, SEM, TEM, measurement of particle size & zeta potential and other in vitro studies were resulted as anticipated. The Syzygium cumini phytosome capsules were found to show better solubility and compatibility with the excipients, it is concluded that Syzygium cumini extract phytosomes has better physical characteristics and improved permeability, solubility than that of extract to overcome ability to cross lipid-rich biological membranes and which results in increase oral bioavailability.