FORMULATION AND EVALUATION OF EFFERVESCENT FLOATING TABLET OF AMLODIPINE BESILATE WITH NATURAL POLYMER CHITOSAN

Abstract

Author(s): Dubey Vivek*, Arora Vandana

Amlodipine Besilate effervescent floating tablets were developed in nine different formulations (F1 to F9) by employing natural polymer (Chitosan) and some other different grades of polymers and effervescent agents such as sodium bicarbonate and citric acid. Direct compression was the technique used for preparing tablets. The formulations were evaluated for various physical parameters, buoyancy studies, dissolution parameters and drug released mechanisms. F5 formulation showed maximum floating time of 12 hours and gave slow and maximum drug release of amlodipine Besilate spread over 12 hours. So the composition of the batch 5 should be optimized, to achieve the goal of formulation and evaluation of effervescent floating tablet of amlodipine Besilate.