HEPATOPROTECTIVE AND HEPATOCURATIVE EFFECTS OF NABK HONEY IN PENICILLIN-INDUCED HEPATIC TOXICITY

Abstract

Author(s): Ateeq M. J. Alarami* and Mohammed S.A.Al-Awar

In our present research, we investigated the hepatoprotective and hepatocurative effects nabk honey in penicillin-induced hepatotoxicity. Biochemical analysis of serum was done for all groups. Hepatotoxicity was confirmed by comparing the serum levels of AST, ALT, ALP, total protein and albumin in penicillintreated group with that of normal salinetreated groups. Nabk honey considerably ameliorated the toxic effects of penicillin on livers. Nabk honey showed the ability to avert the elevated serum AST, ALT and ALP levels, and augmented the total protein and albumin, along with improved histopathological changes in livers. On comparing between hepatoprotective and hepatocurative effects, hepatoprotective effect of nabk honey showed a considerably significant [P < 0.01] improvement in biochemical parameters and morphological changes of livers in penicillin-induced hepatotoxicity. Accordingly, hepatoprotective effect of nabk honey was more effective than hepatocurative effect of nabk honey.