SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL SCHIFF BASES AND THEIR DERIVATIVES AS ANTIMICROBIAL AGENTS

Abstract

Author(s): Pande Harsha. Y, Wadher S. J, Jani Dilip. K

In the present study, Schiff bases of anthranilic acid have been synthesized by reaction with different aromatic aldehydes and the Azetidinones have been synthesized by cyclocondensation of the Schiff’s base with chloroacetyl chloride in the presence of triethylamine. The structures of the newly synthesized compounds were confirmed by IR, 1H NMR, Mass Spectroscopic and Elemental analysis. The synthesized compounds were screened for their in vitro growth inhibitory activity against different strains of bacteria and fungi viz., Staphylococcus aureus, Escheria coli and Aspergillus niger were compared with the standard such as gentamycin (50 μg/ml) and fluconazole (50 μg/ml) by cup plate method. Compounds Ib and IIa exhibits highest antibacterial activity and compound Ia and IIa showed better antifungal activity.