Author(s): Himaja M., Ogale Sachin Ramachandra Rao, Moonjit Dasand Asif Karigar
N-methylated analog of Amidomycin, was synthesized by solution phase peptide synthesis using dicyclohexylcarbodiimide (DCC) as the coupling agent and triethylamine (TEA) as the base. The structure of the compound was confirmed by IR, 1H NMR, 13C NMR, FABMASS and elemental analysis. The synthesized cyclic peptide was evaluated for Minimum Inhibitory Concentration (MIC) against four strains of bacteria and three strains of fungi. It was found to be active against both bacteria and fungi from 50-100 mg.