ANALGESIC EVALUATION OF NOVEL ANTICONVULSANT WITH A CONVENTIONAL ANALGESIC IN DUAL PAIN MODEL OF RAT

Abstract

Author(s): Dhanesh Kumar, Saurabh Kansal, Priti Saxena, Kalpana Chauhan, Abhishek Aggarwal

Gabapentin and carbamazepine like anti epileptics are being used now a days to treat a number of diseases associated with neuropathic pain. The aim of this study is to observe whether novel anticonvulsants are able to produce analgesic response in pain conditions of acute and chronic type. This study observed the analgesic effect of lamotrigine in rats by biphasic nociceptive pain model of formalin test and compared its potency with a conventional opioid analgesic tramadol. Per oral administration of lamotrigine produced no significant effect on early phase response of formalin test but significantly suppressed the late phase response. We conclude that lamotrigine has antinociceptive effect in chronic inflammatory pain as seen by its effect on late phase of formalin test while tramadol has antinociceptive effect both on acute and chronic inflammatory pain.