Author(s): Prajakta P Shinde*, Shahu D Khule
India has rich heritage of use of medicinal plants in clinical practices since ancient times. Diabetes mellitus is a group of syndromes characterized by hyperglycemia, altered metabolism of lipids, carbohydrates and proteins, and an increased risk of complications from vascular disease More than 400 species of plants have been reported to display hypoglycemic effects, but only a few of them have been investigated. Although many drugs are available to control the diabetes but has several adverse effects. The plant Sida cordata was reported to have activities such as Antibacterial, Antitumor, Antifungal, Antiulcer, Antitussive, Anti-inflammatory, Anti-malarial, Antioxidant, Analgesic, Antidepressant, Antihyperglycemic, Hepatoprotective in ayurvedic system of medicine. This study was undertaken to investigate the anti-diabetic activity of methanolic extract of Sida cordata. The two doses (100 and 200 mg/kg) methanolic extract of Sida cordata used for treatment of Alloxan induced diabetic rats. The glucose level was significantly (p<0.01) high in Alloxan control rats when compared with normal control. But the level of glucose was significantly (p<0.01) decreased after 7th day in diabetic rats treated with methanol extract (200 mg/kg) as compared with diabetic control rats.