ASCERTAINING THE MODE OF ACTION OF PHYTOCOMPOUNDS FROM THE MEDICINAL PLANT TINOSPORA CORDIFOLIA USING DOCKING STUDIES

Abstract

Author(s): Muthusamy Jeyam*, Rajendran Banupriya, Vasudevan Poornima

Natural products with medicinal value are progressively gaining importance in clinical research due to their therapeutic uses without any side effects when compared to the available drugs. Tinospora cordifolia (Guduchi) is an important herb in folk and Ayurveda systems of medicine which contains various chemical constituents belonging to different classes such as alkaloids, diterpenoid lactones, glycosides and steroids. The plant is reported to have antimicrobial, antioxidant, anticancer and recurring resistant with promising role against HIV. So, the present study was designed to find the mode of action for the phytocompounds present in the plant T. cordifolia against Swine flu, AIDS and Tuberculosis through in silico studies. Docking studies were performed by using Autodock 4.1 and results were analysed.From the results it was observed that compound columbin exhibited -7.11kcal/mol binding energy, 4 hydrogen bond interactions with ASP25 of the HIV-1 protease receptor. Ecdysterone and Giloin exhibited good binding energy and inhibitory constant against both Neuraminidase and HIV-1 protease receptors.