Author(s): Hemanth Annepogu, Hindustan Abdul Ahad*, Devanna Nayakanti
This present search is to find the best Poly Vinyl Pyrrolidone as a carrier for preparing solid dispersions by taking Etoricoxib as a model drug. Five varieties of Poly Vinyl Pyrrolidone i.e., PVP K-12, PVP K-17, PVP K-25, PVP K-30 and PVP K-90 were studied in this investigation. The drug polymer ratios in these formulations were ranged from 1:1, 1:2, 1:4 and 1:6. The solid dispersions were prepared by microwave fusion method and compressed by tablet punching machine. The prepared tablets were evaluated for physicochemical properties and dug release characteristics. The drug release was further analyzed kinetically with first order and Hixson Crowell’s plots. All the batches of tablets were shown good release characteristics and among the Poly Vinyl Pyrrolidone polymers, PVP K-17 was found to be good as a carrier for increasing the solubility and Release rate from the solid dispersions of Etoricoxib.