ISSN (Online) : 2277-4572
Author(s): Ravi Shrivastava
Presence of free Herpes Simplex Virus (HSV) particles in the vaginal cavity and consequent continuous infection of new healthy cells delay the recovery from Genital herpes (GHSV). As the HSV envelop contains several surface proteins and since some plant tannins have a strong affinity for these proteins, we incorporated specific tannins into an osmotically active solution to evaluate clinical efficacy. 60 women having visible lesions of genital herpes were treated with RPEX (10ml per day) for 14 consecutive days. Product was administered daily into the vaginal cavity and the symptoms of GHSV were evaluated before treatment and on days 1 (2 h), 4, 7, and 14. Smears from GHSV lesions were also collected to evaluate the number of virus-loaded multinucleated giant cells using Tzanck test. Data were analyzed using CFR21 USFDA s o f t w a r e a n d SAS9.1.3. statistical program. The mean amount of free virus was diminished by nearly 17%, 44%, 65%, and 100% on days 1, 4, 7, and 14, respectively, with a corresponding reduction in the size of the lesions, and complete recovery on day 14. HSV surface glycoprotein inhibitors incorporated into an osmotically active solution represents a new approach to treat GHSV.
