Author(s): Atul Bhardwaj *, Riju Agarwal, Manoj Tanwar, Anoop Kumar
Bilvadi medicated oil (BMO) is traditionally used in Ayurveda for the treatment of Hearing loss and tinnitus is enumerated in various text of Indian system of medicine. This current clinical trial as a pilot study is directed to evaluate the effectiveness of BMO when it is used as intratympanic mode through a surgically created window in the tympanic membrane to gain a higher concentration of the BMO in middle ear. 34 patients were selected for the clinical study intends to compare the effectiveness in hearing loss recovery in bilateral and symmetrical presbycusis patients by ramifying them into two trial groups. In one trial group BMO is used in a conventional Karnapoorna manner (Karnapoorna trial group – KPG) while the other trial group was reflected by an intratympanic usage of BMO (Intratympanic group – KPG). On one randomly selected ear KPG clinical trial was commenced and the other ear of the same patient was represented by ITG intervention. Pure tone audiometery (PTA) is used before commencing and after completion of the trial of 30 days and both the ear are compared with degree of hearing loss recovery and results was analysed comparing between Intratympanic and Karnapoorna groups. Intratympanic drug delivery approach was found to be a safe modality to foster the drug delivery to the middle ear and possibly in the internal ear. Presbycusis being primarily a cochlear pathology, higher concentration of drug of required encountering the degenerative and apoptosis related changes of the disease. The traditional Karnapoorna procedure done with the same medicated oil was found to be less effective on hearing recovery and overall recovery parameters probably because of the fact that tympanic membrane epithelial layer is an anatomical barrier in diffusion of the drug in middle ear.