ISSN (Online) : 2277-4572
Author(s): Alemayehu Lelisa Duga, Gizat Molla Kassie, Boressa Adugna Horsa
The treatment option for AIDS have drastically changed since 1987 when the first drug of HIV/AIDS Zidovudin (ZDV) was approved, mono therapy has been replaced by the most effective currently is HAART which includes three drugs from one or all the three categories to decrease incidence of viral resistance. From about, 1,387,039 people living with HIV/AIDS in Ethiopia 167,271 people were initiated on ART by October 2009. The aim of this study is to determine comparative effects of ART on CD4+ cell count in Jimma University Specialized Hospital and assess comparative effects of ZDV and d4T based combinations on CD4+ cell count, to assess comparative effects of EFV and NVP based combinations on CD4+ cell count. Cross-sectional retrospective study was employed. Data (from June 2006 to October 1, 2013) was collected from patient records using data collection format to determine comparative effects of ART regimen on CD4+ cell count in Jimma university specialized hospital. One hundred twenty three patients fulfilled the inclusion criteria and were studied. At six month the EFV based regimens CD4 + cell count had increased with mean of 332 cells/mm3 in the ZDV/3TC/EFV (n = 4) (baseline 139 cells/mm3 ), a mean of 302.36 cells/mm3 in the d4T/3TC/EFV (n = 11) (baseline 102.82 cells/mm3 ) and a mean 283.06 cells/mm3 in the TDF/3TC/EFV (n = 17) (baseline 110.06 cells/mm3 ). The mean CD4 + cell count recoveries of EFV and NRTIs were higher than NVP and NRTIs. ZDV/3TC/EFV mean CD4 count was greater than TDF/3TC/EFV
