Author(s): Murti Yogesh*, Singh Abhay Pratap and Pathak Devender
The 70% hydroethanolic extracts of Calotropis procera (CP) and Calotropis gigantea (CG) leaves have been evaluated and compared for anti-diarrheal activity using castor oil-induced diarrhea model in rats. Results showed statistically significant reduction in the frequency and severity of diarrhoea produced by castor oil in both CP and CG. The anti-diarrheal effect of CP was found superior to CG and inferior to loperamide. It is concluded that CP and CG possess marked antidiarrhoeal activity supporting the folkloric claim that both plants are good remedies for acute nonspecific diarrhoea.