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ISSN (Online) : 2277-4572

DETERMINATION OF SUITABLE METHOD OF PREPARATION OF MICROCAPSULES FOR BOTH WATER SOLUBLE AND INSOLUBLE DRUG

Abstract

Author(s): Himal Barakoti *, Suman Lamichhane, Priyanka Goswami, Ananta Choudhury

In recent years, wide varieties of newer oral drug delivery systems are designed and evaluated in order to overcome the limitations of conventional therapy. Different studies have shown the feasibility of alginate-based microcapsules in the modern approach of drug delivery with safe, effective and well-controlled drug release profile. The aim of the present study was to develop and identify the suitable method for the preparation of microcapsules for both water soluble and water insoluble drug viz. Amoxicillin and Diclofenac sodium respectively, using a natural polymer sodium alginate. Microcapsules beads were prepared by three different techniques: Drug in calcium chloride solution, drug in sodium alginate solution and 3. via soaking technique of drug solution by unmediated microcapsules. It was observed that formulation prepared by soaking unmediated microcapsules in drug solution has the highest percentage yield compared to other techniques (64.11% for amoxicillin and 48.55% for Diclofenac Sodium). Also, higher drug content was found for those microcapsules thus suggesting the highest entrapment efficiency of 56.40 % for Amoxicillin and 68.95% for Diclofenac Sodium respectively. In-vitro dissolution study of prepared microcapsules by different techniques suggested comparatively similar dissolution profile. The study concludes that the microcapsules prepared by soaking of unmediated microcapsules in drug solution resulted in maximum percentage yield along with high drug entrapment efficiency and controlled drug release profile for both drugs. The study is feasible in higher scale and demands a pilot study