Author(s): Yogyata Sandeep Pathare*, Vishakha Samir Hastak, Pranay Anil Kamble
Nasal drug delivery has now been recognized as a very promising route for delivery of therapeutic compounds. In situ gel administration as sprays or drops and may be designed such that they undergo a sol–gel transition at the site of deposition with the implication that the increased viscosity and rheological synergy of the resulting mucus/Mucoadhesive system effects prolonged residence at the site of action2 . The purpose of this research was to formulate the intra nasal In-situ gel of verapamil hydrochloride. Verapamil Hydrochloride is the calcium channel blocker; the half-life of drug is 5 to 7hrs. The intra nasal In-situ gel was prepared to prolong the nasal residence time and to increase its bioavailability. Bioavailability of drug is less i.e. 20 to 35 %. The In-situ gel was prepared by cold technique by using polymers poloxamer 407, poloxamer 188 and HPMC K4M. In-situ gel were evaluated for pH measurement, gelling temperature, drug content, viscosity measurement, determination of mucoadhesive strength, gel strength determination, in vitro drug release, ex vivo permeation study. The formulations were found to be clear, having good in situ gelling capacity, having drug content 96-97%, showed controlled drug release over 24 hours period, the release kinetic study showed that the formulation followed first order controlled diffusion and fickian release mechanism. From the results obtained we can conclude that it is possible to formulate intra nasal In-situ gels of verapamil hydrochloride using poloxamer 407 and poloxamer 188.