DOCKING, SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF SOME HEPTAPEPTIDE DERIVATIVES

Abstract

Author(s): Karigar Asif A1, M. Himaja2*, Ashraf Khan3, Saroj Chotelal 3, Sikarwar Mukesh S.4

Docking was done by using Hex software. Docking helps to determine which compounds can be synthesized. Glaucacyclopeptide A is a cyclic heptapeptide isolated from the seeds of Annona glauca, was synthesized by solution-phase peptide technique. Glaucacycloptide A and its N-methylated analogue were synthesized using Dicyclohexylcarbidomide (DCC) and triethyl amine (Et3N) as base. Structures of all the newly synthesized compounds were confirmed by FTIR, 1H NMR and Mass spectral data. Glaucacycloptide analogs were screened for their antitubercular activity and was assessed against M. tuberculosis H37Rv (ATCC 2729411). The compounds exhibit significant antitubercular activity