Author(s): D. A. Ofusori1*, O. A. Komolafe1, O. S. Adewole1, A. A. Abiodun1, A. O Ayoka
The aim of this study was to appraise the antiulcerogenic effect of Croton zambesicus (C. zambesicus) leaf extract in experimentally induced diabetic rats. Thrity-five adult male wistar rats were divided into seven groups (n=5). Group A, control rats; Group B, untreated diabetic rats; Group C, diabetic rats in which C. zambesicus therapy started 2 weeks prior to induction of diabetes; Group D and Group E, diabetic rats administered orally with C. zambesicus leaf extract for 2 and 4 weeks respectively; Group F, normal rats administered orally with C. zambesicus; Group G, diabetic rats administered with glimepiride (2 mg/kg/day). The leaf extract of C. zambesicus significantly (p<0.05) reduced the gastric lesion and normalized the integrity of some of the gastric cells compromised in diabetic animals. In conclusion, this study demonstrated that C. zambesicus leaf extract possesses antiulcerogenic activities in streptozotocin (STZ) induced diabetic rats which may be useful in the management of gastric lesion in diabetes mellitus.