Author(s): Mohammad Afsal*, Sanjiv Karale, Jagadish V Kamath
In Ayurveda classical texts administration of potent psycho-physical rejuvenator formulation comes under Rasayana chikitsa which frees one of diseases and improves quality of life. This study was designed to evaluate the anti-convulsant and antidepressant activity of polyherbal formulation Epic-Q in experimental animal models. The study was conducted by administering high dose (500 mg/kg) and low dose (100 mg/kg) of formulation. The animal models selected wereMaximum Electroshock-induced Seizuresand Isoniazid induced for anticonvulsant activity and forced swim and tail suspension test for antidepressant tests. The study entails that the Epic-Q at a high dose (500 mg/kg) have anticonvulsant activity and it shows a significant decrease in duration of extension phase in comparison with standard drug phenytoinin INH method, it delayed the latency of convulsions in rats in a dose-dependent manner but failed to protect the rats against mortality and it has potent antidepressant action and it shows moderately significant action. Whereas, the low dose (100 mg/kg) have a weak antidepressant action. From the observations of the present study, we found out that the polyherbal formulation Epic-Q has anticonvulsant and antidepressant activity.