EVALUATION OF SAFETY AND HAIR GROWTH PROMOTING ACTIVITY OF TRICHUP CAPSULE

Abstract

Author(s): Soni Hardik*, Rabadiya Ekta, Zaveri Maitreyi, Patel Sonal, Patel Ghanashyam

Large number of people around the world is suffering from hair loss (alopecia) or hair thinning. Though hair loss is not a life threatening health issue it can make life distressful and can thereby affect physical and mental health of human being. To find solution of such problems, an attempt has been made to evaluate the hair growth promotion activity of a herbo-mineral Ayurvedic formulation, Trichup Capsule. Safety of drug was also evaluated by conducting acute toxicity study as per OECD guideline. For evaluation of hair growth promoting activity, selected animals were divided in to three groups where each group was consisting of six animals. TED and TED × 2 group was treated with Trichup Capsule at 171 mg/kg/day and 342 mg/kg/day, p.o., for 30 days respectively. Visual parameters, hair length, hair diameter and serum total protein were determined. At the end of the study, animals did not manifest any signs of toxicity or mortality. Treatment of Trichup Capsule showed significant effect on all visual parameters. Length and diameter of hairs were significantly increased in TED and TED × 2 groups. Serum total protein was also observed to be elevated in TED and TED × 2 groups in comparison to normal control. Present study data revealed that Trichup Capsule is safe and having significant hair growth promoting activity