ISSN (Online) : 2277-4572
Author(s): C H Arun*, Hussain Gazala, Mundugaru Ravi, Ganti Y Basavaraj
The present study was aimed to evaluate the Ashmarighna (antiurolithiatic) property of Kadalikanda Kshara (Test drug) against ethylene glycol (1%) induced urolithiasis in Wistar albino rats. Animals were divided into five groups as six animals in each group. First group served as normal control and received regular rat food and drinking water. Ethylene glycol (1%) was given in drinking water were fed to all other groups (Group 2 – 5). 2 nd group served as only lithiatic control as ethylene glycol (1%) in drinking water. 3rd group Standard drug was given for 14 days (From 15th - 28th day). 4 th & 5 th group received Kadalikanda Kshara (Test drug) at doses of 22.5mg/kg (Therapeutic Equivalent dose - TED), 90mg/kg (Therapeutic Equivalent dose×4 - TED×4) respectively. After 28 days blood & urine samples collected and analyzed for blood and urine parameters. The kidneys were removed sectioned for histopathological examination. The experimental data were expressed as Mean ± SEM of mean and analyzed by one way analysis of variance followed by Dunnett’s multiple “t” test as post hoc test was considered statistically significant. The rats treated with Test drug in both TED and TED ×4 groups has shown significant effect by increasing the volume of urine and elevating pH of urine & has shown very significant reduction in serum uric acid. Histopathology of kidney sections in Group 4 & 5 showed less tissue damage. Kadalikanda Kshara has protective effect in urolithiasis
