ISSN (Online) : 2277-4572



Author(s): Ashish Gorle *, Mohammad Sadeque

In the present study matrix type transdermal patch of Ondansetron hydrochloride was developed by using the blends of two different type of polymeric combinations viz. Ethylcellulose N20 and HPMC K4M with plasticizer polyethylene glycol (PEG-400) and Dibutylphalate. Preformulation studies were carried out using fourier transform infrared (FTIR) spectroscopy and differential scanning Colorimetry (DSC) technique. The prepared formulations were subjected to various physiochemical evaluation tests like moisture loss, moisture absorption, flatness, drug content, thickness etc. In vitro diffusion study was accomplished by the utilization of diffusion cell using commercial semi permeable membrane. Stability of the formulations was also performed to determine the amount of drug present in patch. All the formulations ingredients were found to be appropriate after physiochemical uniqueness of drug and excipients used and there was no notification in major interaction between the drug and polymer used. In vitro release profile showed that formulation of Ethylcellulose N20: HPMC K4M showed faster release of drug from prepared formulations at labortory. By the utlization of dibutyl pthalate retards the release where as formulations prepared with polyethylene glycol rate was not controlled. Addition of highest amount of HPMC increases thickness and weight but not controlled release but alongwith EC better controlled was observed. Formulation was found to intacts when placed at different climatic conditions. Thus, in future such therapy should be utilized which is helpful to prevent nausea and vomiting that may be caused by surgery or by medicine to treat cancer