Author(s): P.K.Lakshmi *, Ginnarapu Supraja , Ruhi Anjum
The main objective of this study was to prepare and evaluate fast dissolving tablets of aripiprazole using three different types of superdisintegrants. Various formulations were prepared by direct compression using different concentrations of superdisintegrant i.e. namely Kyron T-104, Kyron T-154 and Kyron T-314. The compatibility studies between drug and excipients were carried out using Fourier Transform Infrared spectroscopy. The blend was evaluated for additive properties. The tablets formulated using factorial design was evaluated for physical properties and in-vitro drug release. From this study formulation containing Kyron T-154 was found to possess better disintegration time of 15 sec, water absorption ratio (77.5 %), and wetting time (22.7 sec) with taste masking property at low concentration and hence formulation containing was Kyron T-154 optimized.