Author(s): G.V. Radha* N. Lakshmi Sravanthi, P. Swetha, Y. Sravani, K. Praveen Kumar
In the present study, an attempt has been made to evaluate mucoadhesive microspheres of nifedipine by orifice ionic gelation method employing sodium alginate and different mucoadhesive polymers (HPMC, carbopol) alone and in combination of different proportions. The compatibility study was done between drug and polymer by FTIR which shows no interaction between the drug and polymer. The prepared microspheres were evaluated for particle size ,angle of repose, carrs index, swelling index, microencapsulation efficiency, percent drug content, drug release, kinetics and mechanism of drug release. The microspheres were found discrete, spherical, free flowing and the particle size was found in the range of 765 to 792µ. The encapsulation efficiency was found in the range of 55 to 69 %. Percent drug content was found to be in the range of 96 to 99 %. All the microspheres showed good muco adhesive property in the in vitro wash off test. Drug release from the microspheres was found slow, followed first order kinetics with non fickian release mechanism and release dependent on nature and concentration of polymers.