Author(s): Bharat W. Tekade, Umesh T. Jadhao, Pankaj H. Bari *, Dipali G.Chaudhary. Vijay. R. Patil
The objective of this research work was to formulate and evaluate the floating drug delivery system containing Pantoprazole tablets were prepared by direct compression technique. Formulations contained Limonia acidissima, Xanthan gum, and gas generating agent such as sodium bicarbonate and citric acid. Physical parameters like hardness, weight variation, thickness and friability were within pharmacopoeial limit. Percentage drug content in all floating tablet formulations was found to be 90% to 110%. A lesser floating lag time and a prolonged floating duration could be achieved by varying the amount of effervescent and using different polymer combinations. The in vitro drug release profiles obtained for tablets (F3) made with combinations of Limonia gum and xanthan gum showed lesser floating lag time(46 s) and a prolonged floating duration (18 hrs) which was a sustained release characteristic ( 94.30%) for 18h. Hydrophilic polymer like Limonia gum (10%) and Xanthan gum (10%) was found to be optimum. Xanthan gum was useful in the formation of matrix and Limonia gum was used as a drug release retardant. Among all the formulation, F4 showed drug release upto 94.30% at the end of 18 hours.