Author(s): B.Vishnu Vardhan Reddy, G.dinesh Babu, A.Premswaroop, M.Chandra Sekhar, Ramya.Y3
The present study was carried out to formulate Risperidone mini tablets filled into hard gelatin capsule, as it is administered for the treatment of psychosis. The preformulation studies of Risperidone were carried out and drug –polymer compatibility studies were performed by FT-IR spectra analysis. The precompression parameters revealed that all the 6 formulations had good flow Carr’s index, Hausner’s ratio and angle of repose within the limit. Risperidone is formulated with different concentration of polymers like HPMCK100M, HPMCK15M, filler like lactose and with other excipients. A total number of 6 formulations (F1,F2,F3,F4,F5 and F6)were carried and evaluated. In all the formulations thickness varies between 3.90-3.94mm and the hardness of the optimized batch was found to be 3.18kg/cm2 .No variation in the hardness was found in the optimized formulation that showed powder blending was uniform. Among 6 formulations, F1, F2, F3 and F6 trials were done using K100M polymer and F4, F5 with K15M polymer using optimized quantity of lactose, best batch among those is F1 because it had 90% drug release and it could sustain its action until 20thhr, and is very economical.