ISSN (Online) : 2277-4572
Author(s): Singh Rampal *, Juyal Divya, Singh Vikram, Rawat Geeta
The present research has been undertaken with the ambition to formulate, optimize and evaluate the gel containing Eugenia caryophyllus oil. The gel formulation was designed by using oil which obtained from the leaves of Eugenia caryophyllus. The gel was prepared by using aceclofenac (API) and optimum ratio of carbopol 941 P and HPMC K15M and other excipients are propylene glycol, triethanolamine, and methyl paraben. The Eugenia caryophyllus oil was used as a penetration enhancer. All prepared gel formulations were evaluated by pH, spredability, extrudability, viscosity, drug contents, in- vitro permeability studies and drug- polymer compatibility (FTIR studies). The absorption maxima of aceclofenac were found at 273 nm using pH 6.8 phosphate buffer solutions. The pH values of all formulation was in the range between 6.81 -7.13. Drug content of all formulation ranges from 82.00 – 88.89%. The result value of spreadability was range from 11.00 - 14.00(gm. cm / sec). Whereas the extrudability value of gel formulations from the collapsible tube varies range from 160.00 to 222.22 (gm.cm2 ) and the viscosity of formulations ranges from 18554 cps to 20782 cps at 50 rpm. The % cumulative drug release range from 42.52 -63.02% in 6 hr.
