Author(s): Thatipelli Ravi Chander and Yellu Narsimha Reddy
Present study was aimed to Hepatoprotective Activity with fractions of Evolvulus alsinoides extracts on paracetamol induced Rats. Traditionally this plant used in various types of liver disorders like antihypertensive, hair growthing, antioxidants etc. prepared with various fractions of Evolvulus alsinoides; conducted acute toxicity study on mices to identifying of LD50 value. By using various fractions to conducted Hepatoprotective activity by paracetamol induced method. The blood samples were collected for various biochemical parameters and dissected the liver for histopathological studies. With the above biochemical parameters toxic group of Paracetamol showed the elevated levels of SGPT, SGOT, ALP, CHOL and TBL where as decreased TP and ALB levels when compared with the control group. When fractions of Evolvulus alsinoides produced significant inhibition of hepatic damage by significantly (P < 0.01) reversing the effects of Paracetamol induced hepatotoxicity. Histopathological studies revealed that of Evolvulus alsinoides exhibited a remarkable recovery as Silymarin does. The results of this study strongly indicate that leaves of Evolvulus alsinoides have potent hepatoprotective against Paracetamol. Keywords: Evolvulus alsinoides, Paracetamol, Silymarin.