Author(s): Sangita M. Lavate*, Sucheta A. Gaikwad, Shivajirao S. Kadam and Nirmala R. Deshpande
Aim of our study is to evaluate the anthelmintic activity of different solvent extracts of Aglaia lawii leaves. Natural products play an important role in the discovery and development of new pharmaceuticals. The development of anthelmintic resistance, side effects and the cost of conventional anthelmintic drugs led to the evaluation of medicinal plants as an alternative source of anthelmintics. Aglaia species has a long history of traditional use as an anthelmintic. So the present study is aimed to carry out the anthelmintic activity of various extracts of Aglaia lawii. Air shade dried and pulverized plant material was refluxed with ethyl acetate, acetone, ethanol and methanol solvents and respective extracts were screened for activity using Eicinia foeitida. Albendazole is used as standard. The anthelmintic assay was carried out as per the method of Nargund with minor modifications. It was observed that all the extracts of Aglaia lawii leaves have exhibited positive response to certain degree of anthelmintic activity in dose dependent manner. Acetone and methanol extracts of plant material exhibits significant activity at all dilutions as compared to the standard. Ethyl acetate extract is the least active among four extracts. The rate of paralysis as well as death is higher at more concentrated extracts. The results indicate that acetone and methanol extracts are more potent than ethyl acetate and ethanol extracts. It is concluded based on the findings of the present study that the leaves of Aglaia lawii possess varying degree of anthelmintic activities. The dose of the extract is increased, a gradual increase in the activity of extracts. Acetone and methanol extracts exhibited significant anthelmintic activity at highest concentration of 30 mg/ml. This study strongly supports the traditional use of leaves as anthelmintic.