Author(s): Diwya1, R.Ramachandrappa2, Iyengar Pushpa
Oxidation of Salbutamol (SBL) by sodium – N- chloro benzenesulphonamide(Chloramine-B or CAB) in HClO4 medium has been studied at 303K by kinetic method. Oxidation reaction follows first order kinetics with [CAB], positive fractional order dependence on [SBL] and negative fractional order dependence on [HClO4]. Effect of halide ions, added benzenesulphonamide had no effect on the rate of reaction. Variation in ionic strength had no effect on the rate of the reaction indicating that non-ionic species are involved in the rate limiting step. Dielectric effect of the medium showed negative effect. Kinetic parameters were evaluated by studying the reaction at different temperatures. Addition of reaction mixture to aqueous acrylamide did not initiate polymerization showing the absence of free radical species. Oxidation products were identified. TsNHCl of CAB, the reactive oxidant combines with the substrate to give the product. Based on kinetic results, reaction stoichiometry and oxidation products, a suitable mechanism have been proposed.