Ruellia simplex is a perennial plant having height up to 3 feet. This plant leaves and stem both are green in color however leaves are darker green. Plant is native to South America and fould in countries like Brazil, Paraguay, Uruguay, Argentina and Bolivia. The plants' branches from the ground into several woody-based stems with purple elongated leaves. Some species in the genus are suspected to be poisonous, especially those with reddish inflorescence or flowers. The genus Ruellia plants are reported to be used in traditional medicine as an antioxidant. Ruellia simplex lives in tropical and subtropical climate zones and thrives in riverine terrestrial habitats and contains secondary metabolites like flavonoids, alkaloids, tannins, glycosides and triterpenes. Ruellia simplex is reported to have antinociceptive, anti-inflammatory, and antidiabetic activities. This review will help to provide detailed information on recent research done on this plant.