Author(s): Yadaiah P
In Ayurveda, Acharya charaka has explained very clearly regarding the drug absorption, distribution , metabolism and excretion while describing the vamana karma. Further he says that, the drug acts not only by virtue of qualities but also acts by virtue of dravya prabhavat, guna prabhavat and dravya guna prabhavat and also described the general principles of drug action such as where it acts , on what basis it acts etc. The drug, which possesses the characters of Vyavahi (diffuse) Vikasi (spreading nature -without digestion), Ushna (hot) and Teekshna (acute), Anupravana bhava and Urdwabhaga hara (agni and vayu predominant), when it is administered to the patient after preparation, it induces the vamana karma (expels the increased kapha dosha through mouth). Chakrapani was having the idea of embolism in those days itself. Asajjannamiti(Na kwachidapi Sanga Gacchati) the detached malas (toxins) from the cells are not obstructing any where even in smallest capillaries, indicates the detached malas should not form embolism. It explains metabolism and absorption of the drug. After administration of vamana drug within 1-2 hours we can observe the total procedure with signs& symptoms and results of samyak vamana. On the contrary, when physician is not taking proper care in selection of the drug & dose and preparation of the patient, leads to so many complications. In this paper, the emphasis has been made to explain the pharmacokinetics of vamana drug with conceptual and as well as clinical experience. In this way, one should study and understand each and every drug action before using it.