ISSN (Online) : 2277-4572
Author(s): Manoj Goyal*, Narendra Prajapati
The aim of the present study was to improve the dissolution rate and oral bioavailability of a poorly water soluble drug, itraconozole (ITR) by its adsorption on a porous calcium silicate (FLR). The drug was adsorbed on FLR by adsorption method. solid dispersion of various composition were prepared using Porous Calcium Silicate (FLR), Silicic Acid, Colloidal Silica and Silica Gel (Neutral) (2:1, 1:1, 1:2, 1:3, Physical mixture). Crystallinity of the drug in the solid dispersion was evaluated by differential scanning calorimetry and powder X-ray diffraction analysis. Itraconazole was released at a much higher rate from solid dispersion and physical mixture as compared to that as of itraconazole faster dissolution was exhibited by solid dispersion containing 1:2 ratios of drug and polymer compared to physical mixture and itraconazole. The increase in dissolution rate of the drug may be due to decrease in crystalinity.
