Author(s): Zeinelabdin Salim M.A, P. K. Lakshmi *
The objective of the study was to prepare and evaluate orally disintegrable tablets of olanzapine using Borassus flabellifer starch and Ipomea batatas starch for its superdisintegrant activity. The starches were modified using phosphorylation method with disodium hydrogen orthophosphate anhydrous. DSC analysis revealed that there was no interaction between olanzapine and excipients used in the tablet formulations. Pre-compression parameters were conducted for all formulations blend and were found to be satisfactory. Different concentrations of 3% to 10% of starches were used in the formulation to study the improvement in the ODT parameters. The optimized formulation was compared for its super disintegrant activity with spray dried lactose as diluent and the results were compared but not significantly different. Modified Ipomea batatas starch showed better DT of 16 & 19 seconds (9% and 10%) respectively in comparison to unmodified ipomea starch showed DT of 33 & 45 seconds (9% and 10%) which mean that there is no significant change in DT and no use of modification of starch. The modified borassus starch showed better DT of 20 & 22 seconds (9% & 10%) respectively in comparison to unmodified borassus starch showed DT of 99 & 115 seconds (9% & 10%) which was significantly different & here the modification of starch was useful to improve disintegration time. The dissolution parameters of all formulations did not show any significant difference in release profile. The formulations were optimized using ODT parameters such as disintegration time, wetting time, water absorption ratio and other physiochemical evaluation parameters. To conclude, Ipomea batatas starch in higher concentration (9% & 10%) can be used as supredisintegrant without any modification unlike Borassus flabellifer starch which needs modification to set superdisintegrant activity.