Author(s): Cheraghi Maria, Najafian Mahin, Zargar Mahvash
Hot flash is a common problem of women in menopause and post menopause (climacteric). Despite the fact that hormonal treatments are considered as the most effective therapies, they are not used for the treatment of hot flashes, because they may increases the risk of breast cancer and cardiac diseases. Therefore, we aimed the efficacy of Fluoxetine in treatment of postmenopausal hot flashes A randomized clinical controlled trial was conducted at obstetrics and Gynecology clinic at Razi medical and educational center, Ahvaz, Iran during year 2011. A total of 120 menopause women were participated in this study for 8 weeks follow- up. The subjects were divided into two groups. 60 subjects were selected to treat with fluoxetine (20 mg as one capsule per day), and 60 subject got placebo as control group. Frequency of hot flashes was evaluated during one week, two weeks, four weeks and eight weeks. Data was analyzed using SPSS, version 16. The mean number and severity of hot flashes in fluoxetine group was less than placebo, and showed meaningful difference. The rate of side effects was equal in both groups. Fluoxetine was effective in treatment of hot flashes. It is a cheap and accessible drug, and does not cause the incidence of breast cancer and cardiovascular disease.