SERO EVALUATION OF COINFECTION OF HIV AND HSV-2

Abstract

Author(s): VC Bharathi*, Anaparty Usharani

Prevalence of HSV-2 has been increasing since 1980s with emergence of HIV pandemic which has become a major public health problem in developing countries like India. Objectives of the study was to determine the sero prevalence of HSV-2 in HIV sero positive individuals attending ICTC, GGH, Vijayawada AP, India and to find out influence of risk factors like promiscuity, occupation, migration and illiteracy on acquisition of HSV-2 and HIV. Blood samples were collected from individuals of 20-50 age group attending ICTC centre, GGH, Vijayawada after taking informed consent during the period July 2010 to December 2010 .HIV status was determined by using three ag kits as per NACO guidelines.130 HIV sero positive were tested for Abs to HSV-2 type specific Glycoprotein Ag by ELISA ( Eurocumin). In 130 HIVsero positive individuals 63(48.46%) were HSV-2glycoprotein Ag. Positive. Mean age 34.5+-7.1.Most effected age group was 31-40. Most effected study group truck drivers (60%) followed by migrant labour. (50%) HSV-2 sero positivity was high among males (52.3%). Sero prevalence of HSV-2was high in unmarried people (65.87%). High HSV-2 sero prevalence in drivers, migrant labour, illiterates may be due to ignorance, promiscuity, lack of awareness of STIs. HSV-2 acquisition was high (48.46%) in HIV sero positive persons than in general population (10.7%) indicates that HIV alters the natural history of HSV-2 and accelerates disease progression.