Author(s): S. Nagarjuna *, T.E. Gopala Krishna Murthy, A. Srinivasa Rao
This study describes the solubility and stability profile of naringin and rutin. Solubility of naringin and rutin was studied in different mediums like HCl Buffer pH 1.2, Acetate buffer pH 4. 6, Phosphate buffer pH 6.8 and also in water. Stability studies were also performed for naringin and rutin in HCl Buffer pH 1.2 and Phosphate buffer pH 6.8. The samples were analyzed by using UV Visible spectrophotometer. Naringin and rutin showing very poor solubility profile in all pH media and also in water. Naringin shows highest solubility in acetate buffer pH 4.6 whereas rutin showing highest solubility in phosphate buffer pH 6.8. Naringin shows lowest solubility in water whereas rutin showing lowest solubility in HCl Buffer pH 1.2. Naringin and rutin was stable in both HCl Buffer pH 1.2 and Phosphate buffer pH 6.8. The solubility data in various media is helpful in predicting the bioavailability and also in dissolution method development.