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ISSN (Online) : 2277-4572

SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF CERTAIN NOVEL OXADIAZOLE DERIVATIVES CONTAINING SUBSTITUTED PHENYLIMIDAZOLE MOIETY

Abstract

Author(s): Ahsan Iftikhar, Sharma Kumar K, Sharma Arun, Nager Amit, Kumar Amit

A series of Oxadiazole derivatives (4a-d) have been synthesized from (2, 4, 5-triphenyl-imidazole-1-yl)-acetic acid hydrazide under various reaction conditions. Elemental analysis, IR, 1H NMR and mass spectral data confirmed the structure of the newly synthesized compounds. All the synthesized Oxadiazole derivatives have been investigated for their anti-inflammatory activity showing moderate to good activity.